Increased expression of SOX7 and SOX9, as well as cooperation between SOX7 and SOX4, are involved in the process in which upregulation of slug by SOX4, β-catenin/p300 complexes induces EMT and related CSC properties, which in turn promote homologous and heterologous sarcoma components in UCS (90). The gene discussed is SOX4; the disease is sarcoma.