ZEB1 and central nervous system cancer: It is well known that ZEB1-AS1 is an antisense lncRNA, which is derived from the promoter region of ZEB1. ZEB1-AS1 induced ZEB1 expression in direct or indirect way in different cancers, and it is demonstrated to be closely related to the unfavorable prognosis of malignant tumors such as prostatic carcinoma (38), glioma (46), and hepatocellular carcinoma (47).