Although FUCA1 and FUCA2 both showed prognostic value for patients’ PFI, the diagnostic performance of FUCA1 is more accurate and stable than that of FUCA2. All of these results imply that FUCA1/FUCA2 may be acting in a tumor-suppressive role, and lower expression of FUCA1/FUCA2 prognosticates worse pathological results, less therapeutic effect, and shorter PFI. Here, FUCA2 is linked to neoplasm.