MKI67 and arthritic joint disease: The following covariates for the old cohort: age, education (years), gender, score on the Global Deterioration Scale [51], intake of anti-hypertensive medication, pre-existence of inflammatory disease (e.g. arthritis), intake of statins, alongside corresponding cellular readouts (Ki67, CC3, DCX, Map2) following culture with serum, was analysed using multiple regression tools.