At the molecular level, oligonol positively regulated mitochondrial proteostasis (stimulation of Akt/mTOR/p70S6K and inhibition of FoxO3a/MuRF1 and MAFbx signaling), mitochondrial biogenesis (elevated PGC-1α and Tfam), mitochondrial dynamics (increased Mfn2 and Opa1) and mitophagy (upregulation of PINK1, a reduction in Atg13, LC3-II, and p62, and a decrease in autophagosomes and lysosomes), indicating that oligonol can play a role in the correction of mitochondrial dysfunctions thus preventing sarcopenia. This evidence concerns the gene TFAM and sarcopenia.