During the course of sarcopenia progression in SAMP8 mice, elevated Atg13 and LC3-II levels were associated with the accumulation of p62 and lysosome-associated membrane protein 1 (LAMP1), suggesting that poor fusion between autophagosomes and lysosomes and impaired mitophagy in sarcopenic mice [55]. This evidence concerns the gene SQSTM1 and sarcopenia.