Most included studies revealed that both a single and repeated FUS-MB treatment that induced BBB opening allowed the entry of endogenous immunoglobulin (IgG and IgM) and activated glial cells, which presumably reduced Aβ plaque and p-tau burden and consequently rescued memory and cognitive deficits [15-17, 19, 34, 35]. The gene discussed is CD40LG; the disease is Cognitive impairment.