As shown in Figure 5, pathways closely associated with HCC included the VEGF signaling pathway, p53 signaling pathway, HIF-1 signaling pathway, NF-kappa B signaling pathway, TNF signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway, FoxO signaling pathway, MAPK signaling pathway, estrogen signaling pathway, pathways in cancer, thyroid hormone signaling pathway, focal adhesion, and sphingolipid signaling pathway. The gene discussed is AKT1; the disease is hepatocellular carcinoma.