As shown in Figure 5, pathways closely associated with HCC included the VEGF signaling pathway, p53 signaling pathway, HIF-1 signaling pathway, NF-kappa B signaling pathway, TNF signaling pathway, AMPK signaling pathway, PI3K-Akt signaling pathway, ErbB signaling pathway, FoxO signaling pathway, MAPK signaling pathway, estrogen signaling pathway, pathways in cancer, thyroid hormone signaling pathway, focal adhesion, and sphingolipid signaling pathway. Here, HIF1A is linked to hepatocellular carcinoma.