Moreover, in the conducted studies, the occurrence of insulin resistance is often not taken into account-insulin is a hormone influencing 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA) regardless of thyroid hormones [30] and nicotinism, which are considered modulators of thyroid hormone action on lipid metabolism [31]. The gene discussed is HMGCR; the disease is Insulin resistance.