Diabetes is one of the most common chronic metabolic disorder diseases in the worldwide, over 90% of the diabetes patients are type 2 diabetes mellitus (T2DM), which is characterized by insulin resistance in peripheral tissues and dysregulated insulin secretion by pancreatic beta (β) cells (Banerjee and Vats, 2014; Song et al., 2015). Here, INS is linked to type 2 diabetes mellitus.