LDLRAP1 and familial hypercholesterolemia: To identify pathogenic variants responsible for the hypercholesterolemia of the proband, a customized Gene Panel Test was initially performed to screen for variants within all coding regions of four common familial hypercholesterolemia genes: APOB, LDLR, LDLRAP1, and PCSK9. The sequencing results showed that no family member carried any rare coding variants (<1%, MAF in CHB of 1,000 genomes) in these genes.