ABCG5 and Macrothrombocytopenia: To further determine if heterozygotes of ABCG5/ABCG8 genes could drive hypercholesterolemia and macrothrombocytopenia phenotypes, we created a double knockout rat (Figure 3A), having a growth curve similar to the WT strain without visible abnormalities (Supplementary Figure S4A) and succesful depletion of ABCG5 and ABCG8 expression in liver and intestine (Supplementary Figure S4B).