The discovery of such families with a LDLR gene mutation led to the subsequent identification of genes associated with FH (Vrablik et al., 2020), including APOB, PCSK9, LDLRAP1, ABCG5, and ABCG8. In addition, LRP6 gene mutations associated with LDL cholesterol, triglycerides, hypertension, diabetes mellitus, and osteoporosis (Mani et al., 2007) and DYRK1B gene mutations associated with obesity, severe hypertension, and diabetes mellitus (Keramati et al., 2014) have been reported as familial-onset MI genes that are different from FH and cause MI at a young age. This evidence concerns the gene PCSK9 and diabetes mellitus.