LINC00649 shares a bidirectional promoter with, and (depending on the splice isoform and on the transcription start site used) is antisense to, ATP5O, which encodes an F-type ATPase mitochondrial matrix protein associated with type II diabetes (T2D) in the context of its skeletal muscle mRNA expression profile (Rönn et al., 2009). Here, LINC00649 is linked to type 2 diabetes mellitus.