Previous reports in osteosarcoma, lung, and breast cancer development described different, discrepant modes of RAB11B-AS1 regulation on RAB11B mRNA and protein levels: downregulation (Chen et al., 2018), upregulation (Li et al., 2020) or no effect (Niu et al., 2020) of the sense transcript was observed, generating an inconclusive scenario. The gene discussed is RAB11B; the disease is breast carcinoma.