CHD8 and Intellectual disability: Among them, Chromodomain Helicase DNA-Binding protein 8 (CHD8) is currently one of the highest confidence risk factors (Satterstrom et al., 2020), with de novo haploinsufficiency leading to a genetically defined ASD subtype, characterized by distinctive facial dysmorphisms, macrocephaly (Bernier et al., 2014), mild intellectual disability and postnatal overgrowth (Ostrowski et al., 2019).