C1ORF112, an α-helical protein, is co-expressed with many genes in the BRCA-Fanconi anemia-associated DNA damage response pathway, including BRCA1, BRCA2, FANCD2, and FANCI (Nalepa and Clapp, 2018), and is also modified in some tumors with TP53 mutation (Edogbanya et al., 2021). The gene discussed is FIRRM; the disease is Fanconi anemia.