FIRRM and Fanconi anemia: To explore the possible mechanism of C1ORF112 in LGG, we performed enrichment analysis of C1ORF112 and its co-expressed genes, and found that they were enriched in cell cycle, DNA replication, Fanconi anemia, Mismatch repair, Nucleotide excision repair etc. Previous studies have found that C1ORF112 may influence the Fanconi anemia pathway or its regulation (Liu et al., 1998; Auerbach, 2009).