Smoldering multiple myeloma (SMM) is a pre-malignant condition that precedes symptomatic MM and is defined by a serum monoclonal immunoglobulin (M-protein) of ≥3 g/dL and/or an urinary monoclonal protein ≥500 mg per 24 h, and/or 10–60% clonal bone marrow plasma cells (BMPC), in the absence of end-organ damage (1, 2). Here, MYOM2 is linked to plasma cell myeloma.