Both transcription factors also correlate with genes important for T cell function such as IFNG, IL7, IL7R, IL2RG, CD247 and CD28. Of note, the natural cytotoxicity triggering receptor 1 NCR1 (also known as NKp46, LY94) also correlated with these key genes suggesting that NK cells could also play a role in anti-myeloma cytotoxicity in SMM. Here, CD28 is linked to plasma cell myeloma.