The top upregulated genes in SMM included molecules associated to myeloma (SLAMF7 (CS1), TNFSF13 (APRIL)) key molecules in cytotoxicity (GZMB, GZMA, GZMH, GNLY, HLA-A, HLA-B, PRF1, HLA-C, GZMM) and interleukins playing crucial roles in T cell functions (IFNL1, IL15, IL1A, IL32, TGFB1, IL1B) (Figures 1B, C). The gene discussed is GZMB; the disease is plasma cell myeloma.