LCK and cancer: Interestingly, five genes (CD247, CD3E, ZAP70, LCK, PTPN6) and DEGs between the patients with high-expression and low-expression CD247 were associated with the hsa05235 pathway (PD-L1 expression and PD-1 checkpoint pathway in cancer), and patients with low-expression CD247 had a lower TIL ssGSEA score, which may explain the high incidence of cancer.