In the three datasets, DEGs were mainly enriched in inflammation- and immune-related response and pathways such as neutrophil activation involved in immune response, T cell activation, T cell differentiation, leukocyte chemotaxis, IL-17 signaling pathway, T cell receptor signaling pathway, Th17 cell differentiation, PD-L1 expression, and PD-1 checkpoint pathway in cancer and so on (Figure 7). Here, CD274 is linked to cancer.