Moreover, it is further reported in a clinical trial that the expression of 8/14 genes: BST2, MX1, OAS1, IFIT1, IFITM1, ISG15, RSAD2, and STAT1, were relatively decreased in patients with advanced stage of COVID-19 when compared with that in the early stage, which further evidence the diagnostic feature of this 14-gene profile for COVID-19 severity (42). The gene discussed is ISG15; the disease is COVID-19.