Moreover treatment by metabolically stable apelin analogs, may be also useful for the treatment of autosomal dominant polycystic kidney disease (ADPKD) (119) a disorder linked to excessive AVP secretion, since chronic treatment with tolvaptan, although effective, may be associated with intense thirst, polyuria (24 h diuresis around 6 L/day), nocturia (120) and a rapid plasma sodium concentration correction (121, 122). Here, APLN is linked to autosomal dominant polycystic kidney disease.