APLN and Hyponatremia: The administration of LIT01-196 (900 nmol/kg, s.c.) for two days in this rat model of hyponatremia, by re-establishing the “AVP/(apelin + LIT01-196)” balance, inhibited the effects of AVP on urine output and urine osmolality effectively, and induced a progressive correction of plasma sodium levels (86) (Figure 4).