The overproduction of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, and IL-6, has been widely acknowledged as the pivotal factor involved in the pathogenesis of RA (Feldmann et al., 1996; Kanai et al., 2020; Zhang et al., 2021). This evidence concerns the gene TNF and rheumatoid arthritis.