Apatinib is an oral small-molecule tyrosine kinase inhibitor (TKI), which can competitively bind to the tyrosine ATP binding site in vascular endothelial growth factor receptor (VEGFR), selectively inhibit the activity of VEGFR tyrosine kinases, and block the downstream signaling, therefore suppressing the tumor angiogenesis (Roviello et al., 2016; Geng et al., 2018; Meng et al., 2020). The gene discussed is KDR; the disease is neoplasm.