For example, aberrant expression of immune checkpoints (ICs) components, such as the programmed cell death protein 1 (PD-1), cytotoxic T lymphocyte-associated protein 4 (CTLA-4), T-cell immunoglobulin and mucin domain-containing lymphocyte activation gene 3 (LAG-3), and LAG-3 with Ig and ITIM structural domains T-cell immune receptors (TIGIT), creates an immune destructive environment that promotes tumor cells escape immune destructions (Saleh et al., 2020). This evidence concerns the gene LAG3 and neoplasm.