As a tumor suppressor in most cancers such as breast cancer (Bassi et al., 2016), gastric cancer (Sakuraba et al., 2011) and advanced stage colorectal cancer (Mattera et al., 2009), downregulation of Tip60 leads to defective DNA repair inducing the accumulation of genetic mutations that can cause tumor progression (Bassi et al., 2016). This evidence concerns the gene KAT5 and cancer.