CD8A and neoplasm: Sirt1 could enhance the tumor killing ability of macrophages, and deacetylate K310 of the p65 subunit in NF-κB, thereby increasing the infiltration of CD8+T cells in tumors or increasing the expression of CXCL10, so as to recruit NK cells and macrophages into tumor microenvironments (Yu et al., 2016a; Yu et al., 2016b; Zhou et al., 2019; Ye et al., 2020).