In addition, NextA, a selective HDAC6 inhibitor, was found to increase the proportion of M1/M2 macrophages in tumor microenvironments, promoting IFN-γ and IL-2 levels and transformation of tumor microenvironments from “cold” to “hot”, thus enhancing the efficacy of immune checkpoint blocking therapy (Knox et al., 2019b). This evidence concerns the gene IL2 and neoplasm.