IFNB1 and neoplasm: Inhibition of HDAC1 promoted acetylation of histone H3/H4 in IFN-β1 promoter, and enhanced phosphorylation of interferon regulatory factor (IRF) 3 and its binding to the IFN-β promoter, which could lead to an anti-tumor immune response of macrophages microenvironment (Mounce et al., 2014; Meng et al., 2016).