Meanwhile, HDAC6 binds to cytoplasmic Foxo1 at K242 and deacetylates Foxo1 to weak the stability of Foxo1 and inhibit nucleus translocation, which limits IL-17–producing helper T (TH17) pathogenicity and antitumor effect in hepatocellular carcinoma (Qiu et al., 2020). Here, FOXO1 is linked to hepatocellular carcinoma.