Knockdown of GCN5 and PCAF in osteosarcoma and lung cancer resulted impaired induction of the natural killer group 2D (NKG2D) ligand Rae-1 by IL-12 and the chemotherapeutic agent doxorubicin as inhibition of NKG2D ligand expression was associated with tumor cell death and accelerated tumor progression (Hu et al., 2017). The gene discussed is KLRK1; the disease is osteosarcoma.