Knockdown of GCN5 and PCAF in osteosarcoma and lung cancer resulted impaired induction of the natural killer group 2D (NKG2D) ligand Rae-1 by IL-12 and the chemotherapeutic agent doxorubicin as inhibition of NKG2D ligand expression was associated with tumor cell death and accelerated tumor progression (Hu et al., 2017). This evidence concerns the gene KLRK1 and lung carcinoma.