However, opposite studies have shown that HDAC8 inhibition increases the expression of NKG2D ligand in glioma cells which enhanced the recognition ability and cytotoxicity of NK cells, and activates immune cells in hepatocellular carcinoma resulting in an effective and lasting response to ICB (Yang W. et al., 2021; Mormino et al., 2021). Here, HDAC8 is linked to hepatocellular carcinoma.