On the contrary, PCAF was reported to be highly expressed in HCCs and to promote tumor progression via acetylation of phosphoglycerate kinase 1 (PGK1), pyruvate kinase M2 (PKM2), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which subsequentially induces the Warburg effect and activates Akt signaling (Zheng et al., 2013; Wang T. et al., 2018). This evidence concerns the gene GAPDH and neoplasm.