CD38 and colorectal carcinoma: Using peripheral blood mononuclear cells (PBMCs) from CRC patients, compared to healthy donors, they observed an increased frequency of CD38+ monocytic-myeloid-derived suppressor cells (M-MDSCs) and CD38+ ppolymorphonuclear-myeloid-derived suppressor cells (PMN-MDSCs) compared to healthy monocytes, with the ability to induce immunosuppressive properties (Karakasheva et al., 2018).