According to Chowdhry et al., colon cancer cells appear to be NAMPT-dependent, due to lower levels of NAPRT in the primary tissue (Chowdhry et al., 2019), even though other manuscripts reveal a dependence also from NAPRT (Hong et al., 2019) and a higher expression of this latter enzyme in healthy small intestine, colon cancer cell lines and biopsies (Hara et al., 2007; Duarte-Pereira et al., 2016; Cole et al., 2017). Here, NAPRT is linked to malignant colon neoplasm.