A study by Reddy et al. (Reddy et al., 2004) demonstrated the upregulation of gene expression involved in the regulation of mitochondrial metabolism in a Tg2576 transgenic mouse model transfected with the APP Wt gene as early cellular changes during the progression of Alzheimer’s disease (Swerdlow, 2018). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.