NR4A2 and Alzheimer disease: Importantly, 5XFAD mouse model of AD treated with the Nr4a2 agonist AQ showed robust reduction in typical AD features including deposition of Aβ plaques, neuronal loss, microgliosis and impairment of adult hippocampal neurogenesis, leading to significant improvement of cognitive functions in the Y-maze, which is a behavioral paradigm widely accepted to evaluate spatial working memory.