NR4A2 and Alzheimer disease: A role of Nr4a2 in AD pathology was further supported by the observation that Nr4a2 protein was prominently expressed in brain areas with Aβ accumulation in the 5XFAD mouse model of AD and, notably, it was highly co-expressed with Aβ at mice ages mimicking early stages of the disease (Oakley et al., 2006).