GCKR and nervous system disorder: McGowan et al. (2009) conducted a study in postmortem brains and suggested that similar mechanisms may occur in humans. FZD7 was also identified to be associated with psychiatric or neurological disorders (Hoseth et al., 2018). This subnetwork plays a role in the response to environmental stress [e.g., GCKR (MAP4K5)], long-term memory (ARC), hippocampal neuron (B-Raf), and in regulating cell growth and differentiation (SFRP1).