PrP is a key mediator in several toxicity pathways in some neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) (Prusiner, 2012; Urrea et al., 2017). The gene discussed is PRNP; the disease is amyotrophic lateral sclerosis.