PrPC-expressing COS-7 cells Prnp–/– and C57Bl6 slices Prnp–/– and APPswe/PSen1ΔE9 slices Aβ-containing AD brain Prnp–/– and C57Bl6 slices Synthetic and Aβ-containing AD brain Tg2576 mice and Aβ-containing AD brains Prnp–/– and C57BL/6J slices. The gene discussed is PRNP; the disease is Alzheimer disease.