Another potential reason for elevated NT-proBNP levels in hemorrhagic transformation could be that hemorrhagic transformation aggravated the ischemic stroke-induced neurological injury (Hajdinjak et al., 2012) and could also aggravate stroke-induced cardiac dysfunction in the same way (Chen et al., 2017; Battaglini et al., 2020). This evidence concerns the gene NPPB and ischemic stroke.