Multiple mechanisms might also be behind the prognostic value of NT-proBNP in patients with stroke who underwent intravenous thrombolysis, which could include activated hypothalamic-pituitary-adrenal axis and central autonomic network, impaired blood brain barrier, or unidentified cardiac etiology (Chen et al., 2017; Gopinath and Ayya, 2018; Jiang et al., 2018; Battaglini et al., 2020). This evidence concerns the gene NPPB and stroke disorder.