The association between NT-proBNP and stroke outcome in patients who underwent intravenous thrombolysis was further evaluated in subtypes of stroke, which found that NT-proBNP was associated with functional outcome in large artery atherosclerosis, undetermined etiology, and hemorrhagic transformation in large artery atherosclerosis, however, not remarkable in other subtypes. The gene discussed is NPPB; the disease is stroke disorder.