APP and B cell deficiency: It is noted in a published study that B cell deficiency transgenic mice were constructed in 3×TgAD and APP/PS1 mice by crossing 3×TgAD or APP/PS1 mice with JHT mice, and transient B cell inactivation or depletion was generated in 60- to 70-week-old 3×TgAD and 35- to 47-week-old 5×FAD mice by intraperitoneal injection of anti-B cell antibodies, anti-CD20 (100 μg/mouse) and anti-B220 (250 μg/mouse).