FRAT2 and neurodegenerative disease: In B cells, the upregulated genes KIR3DL2, QPCT, and PPP2R2B are all involved in neural function and neurodegenerative diseases, and the downregulated genes FRAT2 and WWC3 are involved in the Wnt/β-Catenin signaling pathway, which is associated with AD pathogenesis31,32 (Fig. 7b).