The top 100 upregulated genes (ranked by fold change) expressed in B cells during the progression of AD were identified, and the overlapping area showed 18 prominent genes as the disease proceeded: AC109826.1, LINC00239, CTC-505O3.3, DTHD1, CFH, NFE2, QPCT, DAB2, PHLDA1, PPP2R2B, SIRPG, KIR2DL3, FOLR3, KIR3DL2, AOAH, IFNG, CD160, and FCRL6. This evidence concerns the gene FCRL6 and Alzheimer disease.