MAPK8 and cholestasis: In contrast to a previous report that SESN1/2/3 interact and inhibit the activation of JNK in Western diet-induced hepatic lipotoxicity61, we find that during cholestasis, SESN1 does not regulate the activity of JNK, ERK, and p38 (Fig. 4D), which is possibly due to distinct etiologies and cell-specific responses.