While all the four proteins were upregulated by DENV2, ZIKV and CHIKV in SG in the current study, we observed that ADA and GILT-like proteins had virus-specific antiviral properties against CHIKV and ZIKV, respectively, that SGS1 protein had virus-specific proviral function for ZIKV, and that SGBAP protein had broad-spectrum antiviral properties as it reduced infection by all the three viruses. The gene discussed is ADA; the disease is infection.