Importantly, we validated H19, LINC00609, POM121L9P, and SNHG11, which as risk factors of GBM, were significantly upregulated; while AC012615.1, LINC00634, and USP32P3, which as protective factors of GBM, were dramatically decreased in glioma cell lines (U87 and U251), compared to Normal human glial cell line HEB (Fig. 3e,f). Here, SMIM45 is linked to glioblastoma.