The expression level of CDH2(r = 0.263, P = 3.54 × 10−7), CDH6 (r = 0.307, P = 2.04 × 10−9) and CDH10 (r = 0.33, P = 9.99 × 10−11) in GC tumor tissues were closely related to CD4 + T cell immune infiltration. The gene discussed is CDH6; the disease is gastric cancer.