ENSG00000235059 and familial Mediterranean fever: Considering that RhoA-dependent pyrin activation is observed in murine macrophage whose pyrin lacks PRY/SPRY domain31 and that there are differences in clinical symptoms between FMF and PAAND, it is plausible that PRY/SPRY domain of human pyrin has a function for inflammasome formation in a certain manner other than the RhoA-dependent pathway.