In order to evaluate the therapeutic potential of BW in ALS, we then treated transgenic mice expressing the G86R mutation of the murine Sod1 gene (Sod1G86R mice) with either vehicle (n = 38), 1 mg/kg/d (n = 5) or 3 mg/kg/d (n = 31) of BW. Here, SOD1 is linked to amyotrophic lateral sclerosis.