VEGFA and age-related macular degeneration: Post-hoc analyses of multiple major clinical trials including the Comparison of Age-Related Macular Degeneration Treatments (CATT) Trials7 and VEGF Trap-Eye: Investigation of Efficacy and Safety in Wet AMD (VIEW 2) trial8 have shown that intraretinal fluid (IRF) is associated with lower baseline visual acuity (VA) and worse visual outcomes when compared with subretinal fluid (SRF)7,8.