Pathway analysis of genes in this cluster revealed activation of numerous cancer-related pathways including kinetochore metaphase signaling, cell cycle control of chromosomal replication, role of BRCA1 in DNA damage response, mitotic roles of polo-like kinase, hereditary breast cancer signaling, role of CHK proteins in cell cycle checkpoint control, and estrogen-mediated S-phase entry pathways (Fig. 4A, Supplementary Table S2). This evidence concerns the gene BRCA1 and cancer.