CDHR3 and asthma: Several genome-wide association studies (GWAS) have revealed several asthma risk genes, including those encoding the ORMDL Sphingolipid Biosynthesis Regulator 3 (ORMDL3), Gasdermin B (GSDMB), and Cadherin Related Family Member 3 (CDHR3), as well as a number of genes related to innate immunity and immunoregulation6.