ANXA2 and infection: AnxA2 plays an important role in host defense against some bacterial (such as Klebsiella pneumoniae) and fungal (such as Cryptococcus neoformans) infections, but may also be exploited for adhesion, invasion and proliferation by certain bacterial (such as Pseudomonas aeruginosa and Rockettsia australis) and viral (such as human papillomavirus) pathogens61.