As observed in the experimental models of asthma (OVA and HDM induction) where decorin expression was induced in T cells, decorin treatment of Nf1OPG mice reduced tumor proliferation (%Ki67+ cells), with no change in optic nerve volumes, microglia (Iba1+ cells), or T cells (CD3+ cells) in vivo (Fig. 5f, g). This evidence concerns the gene AIF1 and neoplasm.