Importantly, control experiments suggested that these drugs did not directly reduce TRIM43 or significantly impact myoblast differentiation, thereby supporting our hypothesis that RNAi mediated by small molecule upregulation of miR-675 could reduce DUX4 and indirectly decrease a DUX4-responsive biomarker in FSHD muscle cells (Supplementary Note 8 and 9 and Supplementary Fig. 19). The gene discussed is DUX4; the disease is Facioscapulohumeral dystrophy.