SOX2 and glioma: The GISTIC focal amplification peaks showed that, although both of the cancer types significantly amplify the SOX2 gene, they also selectively amplify noncoding regions adjacent to SOX2. Indeed, the squamous cancer peak (chr3:181,415,947–181,719,852) covers SOX2 and a ~290 kb noncoding region 3′ to SOX2, while the glioma peak (chr3:181,256,575–181,496,100) covers SOX2 and a ~173 kb noncoding region 5′ to SOX2 (Fig. 1a).