In 2016 CNS WHO classification, gliomas are further classified by histological and molecular characteristics, including lower-grade gliomas (LGG), isocitrate dehydrogenase-mutant (IDH-mutant) and 1p/19q-codeleted; LGG, IDH-mutant without 1p/19q-codeleted; LGG, IDH-wildtype; glioblastomas (GBM), IDH-mutant; and GBM, IDH-wildtype [3]. The gene discussed is IDH3A; the disease is central nervous system cancer.