In reflecting on the present data and the recent meta-analysis (Cross-Disorder Group of the Psychiatric Genomics Consortium, 2019) which linked a SNP (rs2332700) in RGS6 to autism spectrum disorder, bipolar disorder, major depression, and schizophrenia, it becomes intriguing to speculate on the SNP’s functionality. This evidence concerns the gene RGS6 and schizophrenia.