RGS6 and major depressive disorder: One of the 23 pleiotropic genetic loci described was a SNP (rs2332700) in regulator of G-protein signaling 6 (RGS6), previously identified in a GWAS of schizophrenic patients (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014), that was linked not only to schizophrenia, but also to autism spectrum disorder, bipolar disorder, and major depression.