RGS6 and Anxiety: In particular, alterations in RGS6 signaling and/or expression have been associated with: alcohol use disorders (rs11621871; Stewart et al., 2015; Chen et al., 2017), anxiety/depression (Stewart et al., 2014), Parkinson’s disease (Bifsha et al., 2014; Luo et al., 2019; Petyuk et al., 2021), Alzheimer’s disease (rs4899412; Moon et al., 2015), motor coordination (Maity et al., 2012), adult hippocampal neurogenesis (Gao et al., 2020), as well as human cataracts, mental retardation, and microcephaly (c.