This includes intrinsic glucose variability with higher risk of impaired awareness of hypoglycaemia,22 23 including severe events requiring assistance from others in treatment.24 We hypothesise that mild frailty may have a comparable impact in type 1 diabetes and insulin-treated type 2 diabetes where body mass index (BMI) is <30 kg/m2, with potentially comparable impacts of resistance exercise training.25 This evidence concerns the gene INS and type 1 diabetes mellitus.