The Global Prevalence Studies in Urology Clinics Studies 2003–2010, which included 1866 health care-associated UTI patients, showed that the global resistance rates of overall uropathogens to ciprofloxacin, trimethoprim-sulfamethoxazole, ampicillin and beta-lactamase inhibitors were all over 50% [21]. The gene discussed is LACTB; the disease is bacterial urinary tract infection.