Furthermore, the osteocalcin level and ALP activities in serum were elevated in the osteoporosis model mice (P < 0.05, P < 0.01), and were inhibited in the osteoporosis model mice with the transfection of miR-425-5p mimics (P < 0.01) (Fig. 5F and G). The gene discussed is BGLAP; the disease is osteoporosis.