Furthermore, BCEC-1 cells showed a higher expression of innate response genes including IFIT1, IFIT3, MX2, OAS1Z and RSAD2 than F3 cells already without virus infection (Fig 9E) and in particular upon wt BVDV infection (Fig 9C and 9D columns 5 and 4, respectively, and Fig 9E). This evidence concerns the gene RSAD2 and viral infectious disease.