Likewise, the administration ofmelatonin increased the plasma, liver and adipose nitric oxide concentration anddecreased the plasma and liver uric acid and IL-6 concentration with correspondingdecrease in adipose IL-6 in obese rats compared to the untreated obese group,suggesting that treatment with melatonin mitigates inflammatory signals induced byinsulin resistance/hyperinsulinemia with consequent decrease in adipose/hepaticinflammation. The gene discussed is IL6; the disease is Hyperinsulinemia.