Moreover, AST, ALT, CK, BUN, Hb, Ht, PWT, and LAVI appeared to modify the relationship due to heart failure (p for interaction, 0.021, 0.001, <0.001, 0.003, 0.014, 0.004, 0.045, and 0.031, respectively; Fig 4 and S1 Fig). Here, GSTM1 is linked to heart failure.