We conditioned the gene-wise association of IL18R1 for the p.G423R and observed that the additional amino acid changes remained nominally significantly depleted in the gene (PSKAT-O = 0.02) indicating that an increasing burden of nonsynonymous variants in IL18R1 is protective for leprosy independent of the p.G423R mutation. The gene discussed is IL18R1; the disease is leprosy.